Long-term expansion of basal cells and the novel differentiation methods identify mechanisms for switching Claudin expression in normal epithelia

Abstract Epithelia are tightly connected cellular sheets, that shield our body from the external environment.They are continuously maintained by a pooled population of undifferentiated cells through differentiation.However, the maintenance mechanisms remain incompletely understood due to the difficulty of experimentally observing the differentiatio

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Visualizing differences in phylogenetic information content of alignments and distinction of three classes of long-branch effects

Abstract Background Published molecular phylogenies are usually based on data whose quality has not been explored prior to tree inference.This leads to errors because trees obtained with conventional methods suppress conflicting evidence, and because support values may be high even if there is no distinct phylogenetic signal.Tools that allow an a p

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